Try installing in clean boot mode. See:
http://support.microsoft.com/default.aspx/kb/331796
Something is blocking the registry writes required at the end of an
installation. Possibly an anti-virus app. Clean boot will disable all but
the MS software.
"Rick A" <Rick
> wrote in message
news:1081B778-1991-4EC9-9688-...
>I get the following message on starting Microsoft Streets & Trips 2008
>"Your
> registry settings for this application were not copied correctly. To
> correct
> these settings, run setup again for this application from the location
> where
> you originally installed it." Tried that a number of times with no
> success.
> I even uninstalled the program and reinstalled it with no success. Can
> someone help?