Having problems getting software to run that ran before today

I am getting several problems when I try to run programs that worked
yesterday. I got the updates for 12/12/07 and my problems seem to have
started after that. I tried to run PaperPort 11 and it gives me the error
that I have a problem with win32. I can run other programs with no problems.
This problem is on my Vista business machine. On my newly installed Vista
home premium I am having problems running several programs with no error
messages other than windows is checking for a solution and a solution never
comes. All of these programs are Vista ready. I am also having problems with
explorer. When I open the start button and start typing in something I get
the message that it has the problem and it will find the solution. I have to
close all open windows to get it to work. Does anyone have a solution to all
this madness?