I have the same problem and it is driving me mad. Brand new Dell computer, new Dell mouse, an extra Microsoft mouse, tried several USB ports... The same problem. The "hotspot" is off.
The only that that works sometimes is changing the mouse pointer scheme. That works with the 3d bronze the best (or maybe only one), and again only sometimes, and tempermentally.
I have to point at something with the stem of the pointer, or to adjust screen size, I have to move a whole centimeter down and the the right below the right hand corner of the screen I'm trying to size. It's rather rediculous.
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