Problems with Vista security obsession!

After choosing to reformat my hard drive and do a clean reinstall of Vista,
I've run into some strange problems with Vista security that I wasn't having
before. First of all, When I installed Hotsync Manager (to sync with a Palm
TX handheld), I find that every time I boot up I get a Windows message that
some programs were blocked (in quick launch). I can go in and instruct the
program to let it run each time, but it gets to be a nuisance to have to keep
doing that. This never happened in the original install, before reformatting
the disk, and it doesn't happen with my laptop which is also on Vista. I
wouldn't mind having to verify security once, but there should at least be a
way to say "always allow this program". If there is, I would appreciate help
finding it. Otherwise, does anyone know what might be causing this to happen
in this installation, when it didn't before, and how I can fix it?

I am also having a problem with Windows Mail since the reinstall. Since I
didn't want to lose my email accounts, contacts, email folders, and saved
email, and I hadn't exported any of this, I did a restore from a backup set
(with NovaBackup), and had it overwrite all current files in the Windows Mail
directory. I expected this to work, but I started getting error messages
when I tried running Mail with UAC on, saying that Mail couldn't run. If I
shut off UAC, then Mail would work OK. Also, if UAC is on, I can do a "run
as administrator" on Mail, and then it will work. How can I get Windows Mail
back to running normally without losing everything that's in it?

Thanks for your help.
--
Larry S