Vista Synchronise Mouse Pointer with desktop hotspots

I recently bought a Dell Inspiron 530 running under Vista Home Premium. It
was supplied without a monitor. I have tried it with two monitors, a small
LG flat screen and a 20.5" widescreen Samsung. In both cases the mouse
pointer is about 2 mm (1/8th inch) out of true so that when for example
selecting files from a list in Windows Explorer it is easy to select the one
below that intended. How do I synchronies the mouse pointer with the
hotspots? An obvious answer is to contact Dell, but, if it comes to that, I
would like to have some understanding of the underlying problem before I
talk with them. And if there is some simple registry tweak in Vista, then
hopefully I can fix it with kind guidance from this newsgroup

Video card: 256MB ATI® RadeonT HD 2600 XT graphics card

Doug