Hi BT,
Try this fix from MVP Ramesh:
http://www.winhelponline.com/articles/165/1/
--
Jane, not plain

64 bit enabled :-)
Batteries not included. Braincell on vacation ;-)
MVP Windows Shell/User
"Buford T. Justice" <?@hotmail.com> wrote in message
news:8CE0FFB8-9EC6-43FF-BEA4-...
>I am trying to help an online friend of mine with a strange problem. It is
>Vista Home Premium. For whatever reason, all of her programs try to open
>in Media Center and obviously fail to open. It is almost like the
>reference for .EXE files has been changed would be my initial guess. We
>can't seem to find a way to correct this issue so I thought I would give
>this newsgroup a try. Might anyone have any suggestions to correct this
>issue without doing a Vista reinstall?
>
> Thanks In Advance,
> BT